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The antibody against HM13 was raised in rabbit using the Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against HM13 was raised in rabbit using the Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-24737A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HM13 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8TCT9 |
Uniprot Id
Q8TCT9
Target Species
Human
Target Name
HM13
Target Full Name
Minor histocompatibility antigen H13
Target Function
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.
Target Protein Families
Peptidase A22B family
Target Tissue Specificity
Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
Target Synonyms
dJ324O17.1; H13; hIMP1; Histocompatibility (minor) 13; HM13; HM13_HUMAN; IMP-1; IMP1; IMPAS; IMPAS-1; Intramembrane protease 1; Intramembrane protease; Minor histocompatibility antigen 13; Minor histocompatibility antigen H13; MSTP086; OTTHUMP00000030527; OTTHUMP00000030528; OTTHUMP00000030530; OTTHUMP00000214528; Presenilin-like protein 3; PSENL3; PSL3; Signal peptide peptidase; Signal peptide peptidase beta; SPP
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