Rabbit anti-Human HSD17B6 Polyclonal Antibody

Uniprot Id

O14756

Target Species

Human

Target Name

HSD17B6

Target Full Name

17-beta-hydroxysteroid dehydrogenase type 6

Target Function

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

Target Subcellular Location

Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side.

Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Target Tissue Specificity

Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosu

Target Synonyms

17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 3 hydroxysteroid epimerase ; 3(alpha >beta) hydroxysteroid epimerase ; 3(alpha >beta) hydroxysteroid epimerasel; 3-alpha->,beta-HSE; 3-alpha->,beta-hydroxysteroid epimerase; H17B6_HUMAN; HSD17B6; HSE ; Hydroxysteroid (17 beta) dehydrogenase 6; Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse); Hydroxysteroid 17 beta dehydrogenase 6; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase ; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase; Oxidative 3 alpha hydroxysteroid dehydrogenase; Oxidative 3-alpha hydroxysteroid dehydrogenase; Oxidoreductase ; Retinol dehydrogenase; RODH ; SDR9C6; Short chain dehydrogenase/reductase family 9C, member 6

Target Background

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family.