Rabbit anti-Human ICT1 Polyclonal Antibody

Uniprot Id

Q14197

Target Species

Human

Target Name

MRPL58

Target Full Name

Large ribosomal subunit protein mL62

Target Function

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily

Target Tissue Specificity

Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.

Target Research Area

Metabolism

Target Synonyms

Digestion substraction 1; DS-1; DS1; Ict1; ICT1_HUMAN; Immature colon carcinoma transcript 1; Immature colon carcinoma transcript 1 protein; mitochondrial; Peptidyl-tRNA hydrolase ICT1; Peptidyl-tRNA hydrolase ICT1, mitochondrial

Target Background

The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene.