Rabbit anti-Human IFNAR2 Polyclonal Antibody

Uniprot Id

P48551

Target Species

Human

Target Name

IFNAR2

Target Full Name

Interferon alpha/beta receptor 2

Target Function

Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; Potent inhibitor of type I IFN receptor activity.

Target Involvement

Immunodeficiency 45 (IMD45)

Target Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

Target Protein Families

Type II cytokine receptor family

Target Tissue Specificity

Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Human interferon alpha/beta receptor; IFN alpha REC; IFN R; IFN-alpha binding protein; IFN-alpha/beta receptor 2; IFN-R-2; IFNABR ; IFNAR2; IFNARB ; IFNR; INAR2_HUMAN; Interferon (alpha beta and omega) receptor 2; Interferon alpha binding protein; Interferon alpha/beta receptor 2; Interferon alpha/beta receptor beta chain; Type I interferon receptor 2; Type I interferon receptor

Target Background

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45.