Rabbit anti-Human IL-1 alpha Polyclonal Antibody

The antibody against IL-1 alpha was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 112-271 of human IL-1 alpha (NP_000566.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11306A

Number

Cat.No	ADA-11306A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	IL-1 alpha
Target Synonyms	IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	RAW264.7	Application	ELISA, WB

Cat.No

ADA-11306A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

IL-1 alpha

Target Synonyms

IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

RAW264.7

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 112-271 of human IL-1 alpha (NP_000566.3).	Target Species	Human
Immunogen Sequence	RSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA	Uniprot ID	P01583

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 112-271 of human IL-1 alpha (NP_000566.3).

Target Species

Human

Immunogen Sequence

RSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA

Uniprot ID

P01583

Background Information

Uniprot Id

P01583
Target Species

Human
Target Name

IL1A
Target Full Name

Interleukin-1 alpha
Target Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Target Subcellular Location

Cytoplasm. Secreted.
Target Protein Families

IL-1 family
Target Research Area

Immunology
Target Synonyms

BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; Interleukin 1 alpha; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha
Target Background

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

Rabbit anti-Human IL-1 alpha Polyclonal Antibody

Specifications

Immunogen Information

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