Rabbit anti-Human ING4 Polyclonal Antibody

Uniprot Id

Q9UNL4

Target Species

Human

Target Name

ING4

Target Full Name

Inhibitor of growth protein 4

Target Function

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11.

Target Subcellular Location

Nucleus.

Target Protein Families

ING family

Target Synonyms

Brain my036 protein; Candidate tumor suppressor p33 ING 1 homolog; Candidate tumor suppressor p33 ING1 homolog; D6Wsu147e; D6Xrf92; ING 1 like protein; ING 4; ING1 like protein; ING4; ING4_HUMAN; Inhibitor of growth family member 4; Inhibitor of growth family member 4 long isoform; Inhibitor of growth protein 4; MGC12557; my036; p29 ING 4; p29 ING4; p29ING4

Target Background

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.