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The antibody against INPP5F was raised in rabbit using the Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against INPP5F was raised in rabbit using the Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-01938A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INPP5F |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y2H2 |
Uniprot Id
Q9Y2H2
Target Species
Human
Target Name
INPP5F
Target Full Name
Phosphatidylinositide phosphatase SAC2
Target Function
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries.
Target Subcellular Location
Membrane, clathrin-coated pit. Early endosome. Recycling endosome.
Target Tissue Specificity
Ubiquitous. Highly expressed in brain.
Target Synonyms
INPP5F; KIAA0966; SAC2; MSTP007; MSTP047; Phosphatidylinositide phosphatase SAC2; EC 3.1.3.25; Inositol polyphosphate 5-phosphatase F; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2; hSAC2
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