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The antibody against KCND1 was raised in rabbit using the Recombinant Human Potassium voltage-gated channel subfamily D member 1 protein (410-647AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against KCND1 was raised in rabbit using the Recombinant Human Potassium voltage-gated channel subfamily D member 1 protein (410-647AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human brain tissue using KCND1 Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using KCND1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
Immunohistochemistry of paraffin-embedded human testis tissue using KCND1 Antibody at dilution of 1:1003
| Cat.No | ADC-46316A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KCND1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Potassium voltage-gated channel subfamily D member 1 protein (410-647AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NSA2 |
Uniprot Id
Q9NSA2
Target Species
Human
Target Name
KCND1
Target Full Name
A-type voltage-gated potassium channel KCND1
Target Function
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cell projection, dendrite.
Target Protein Families
Potassium channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.1/KCND1 sub-subfamily
Target Tissue Specificity
Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.
Target Research Area
Neuroscience
Target Synonyms
Kcnd1; KCND1_HUMAN; Kv4.1; mShal; OTTHUMP00000025805; OTTHUMP00000025806; Potassium voltage gated channel Shal related subfamily member 1; Potassium voltage gated channel subfamily D member 1; Potassium voltage-gated channel subfamily D member 1; Shal type potassium channel; Voltage gated potassium channel Kv4.1; Voltage gated potassium channel subunit Kv4.1; Voltage-gated potassium channel subunit Kv4.1
Target Background
This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction.
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