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The antibody against KCTD6 was raised in rabbit using the Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against KCTD6 was raised in rabbit using the Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lung tissue using KCTD6 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using KCTD6 Antibody at dilution of 1:1002
| Cat.No | ADC-19067A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KCTD6 |
| Target Synonyms | BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NC69 |
Uniprot Id
Q8NC69
Target Species
Human
Target Name
KCTD6
Target Full Name
BTB/POZ domain-containing protein KCTD6
Target Function
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
Target Subcellular Location
Cytoplasm, myofibril, sarcomere, M line.
Target Tissue Specificity
Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
Target Synonyms
BTB/POZ domain-containing protein KCTD6; KCASH3; kctd6; KCTD6_HUMAN; MGC27385; potassium channel tetramerization domain containing 6
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