Rabbit anti-Human KIF13A Polyclonal Antibody

Uniprot Id

Q9H1H9

Target Species

Human

Target Name

KIF13A

Target Full Name

Kinesin-like protein KIF13A

Target Function

Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Note=Recruited to the midbody during cytokinesis.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family

Target Tissue Specificity

Widely expressed, with highest levels in heart, brain and skeletal muscle.

Target Synonyms

bA500C11.2 ; FLJ27232; Homolog of mouse KIF13A mannose 6 phosphate receptor transporter; KI13A_HUMAN; KIF 13A; Kif13a; Kinesin family member 13A; Kinesin like protein KIF13A; Kinesin like protein RBKIN ; Kinesin-like protein KIF13A; Kinesin-like protein RBKIN; RBKIN

Target Background

This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants.