Rabbit anti-Human KNTC1 Polyclonal Antibody

The antibody against KNTC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 900-1100 of human KNTC1 (NP_055523.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11155A

Number

Cat.No	ADA-11155A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	KNTC1
Target Synonyms	ROD; KNTC1	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T	Application	ELISA, WB

Cat.No

ADA-11155A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

KNTC1

Target Synonyms

ROD; KNTC1

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 900-1100 of human KNTC1 (NP_055523.1).	Target Species	Human
Uniprot ID	P50748	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 900-1100 of human KNTC1 (NP_055523.1).

Target Species

Human

Uniprot ID

P50748

Immunogen Sequence

Background Information

Uniprot Id

P50748
Target Species

Human
Target Name

KNTC1
Target Full Name

Kinetochore-associated protein 1
Target Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
Target Subcellular Location

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.
Target Tissue Specificity

High expression in testis.
Target Synonyms

KNTC1; KIAA0166Kinetochore-associated protein 1; Rough deal homolog; HsROD; Rod; hRod

Rabbit anti-Human KNTC1 Polyclonal Antibody

Specifications

Immunogen Information

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