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The antibody against Lamin B2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 341-620 of human Lamin B2 (NP_116126.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against Lamin B2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 341-620 of human Lamin B2 (NP_116126.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-02999A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Lamin B2 |
| Target Synonyms | EPM9; LMN2; LAMB2; MCPH27; Lamin B2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, 293T, HepG2, MCF7, Mouse liver, SW620 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 341-620 of human Lamin B2 (NP_116126.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q03252 | Immunogen Sequence |
Uniprot Id
Q03252
Target Species
Human
Target Name
LMNB2
Target Full Name
Lamin-B2
Target Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Target Involvement
Partial acquired lipodystrophy (APLD); Epilepsy, progressive myoclonic 9 (EPM9)
Target Subcellular Location
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
Target Protein Families
Intermediate filament family
Target Synonyms
EPM9; LMN2; LAMB2; MCPH27; Lamin B2
Target Background
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.
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