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The antibody against LIG3 was raised in rabbit using the Recombinant Human DNA ligase 3 protein (809-928AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against LIG3 was raised in rabbit using the Recombinant Human DNA ligase 3 protein (809-928AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using LIG3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using LIG3 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using LIG3 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-15917A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LIG3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA ligase 3 protein (809-928AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49916 |
Uniprot Id
P49916
Target Species
Human
Target Name
LIG3
Target Full Name
DNA ligase 3
Target Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair.
Target Subcellular Location
[Isoform 1]: Mitochondrion.; [Isoform 2]: Mitochondrion.; [Isoform 3]: Nucleus.; [Isoform 4]: Nucleus.
Target Protein Families
ATP-dependent DNA ligase family
Target Tissue Specificity
Testis, thymus, prostate and heart.
Target Synonyms
D11Wsu78e; DNA ligase ; DNA ligase 3; DNA ligase III; DNLI3_HUMAN; LIG 3; LIG2; LIG3; Ligase II; DNA; ATP dependent; Ligase III DNA ATP dependent; MGC78176; OTTMUSP00000000875; Polydeoxyribonucleotide synthase [ATP] 3; Polydeoxyribonucleotide synthase [ATP]; Polydeoxyribonucleotide synthase; RP23-316C11.6
Target Background
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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