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The antibody against MAJIN was raised in rabbit using the Recombinant Human Membrane-anchored junction protein (1-216AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MAJIN was raised in rabbit using the Recombinant Human Membrane-anchored junction protein (1-216AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human tonsil tissue using MAJIN Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using MAJIN Antibody at dilution of 1:1002
| Cat.No | ADC-20151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAJIN |
| Target Synonyms | MAJIN antibody; C11orf85Membrane-anchored junction protein antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Membrane-anchored junction protein (1-216AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q3KP22 |
Uniprot Id
Q3KP22
Target Species
Human
Target Name
MAJIN
Target Full Name
Membrane-anchored junction protein
Target Function
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.
Target Subcellular Location
Nucleus inner membrane; Single-pass membrane protein. Chromosome, telomere.
Target Protein Families
MAJIN family
Target Synonyms
MAJIN; C11orf85Membrane-anchored junction protein
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