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Rabbit anti-Human MC2R Polyclonal Antibody

The antibody against MC2R was raised in rabbit using the Synthetic peptide of Human MC2R as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

ADC-28183A

The antibody against MC2R was raised in rabbit using the Synthetic peptide of Human MC2R as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

$299.00

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Specifications


Cat.No ADC-28183A ClonalityPolyclonal
Host SpeciesRabbitTarget NameMC2R
FormLiquidSpecies ReactivityHuman, Mouse
IsotypeIgGStorage Buffer0.05% NaN3, 40% Glycerol., pH7.4 PBS
Purification MethodAntigen affinity purifiedConjugateNon-conjugated
ApplicationELISA, WBStorageUpon receipt

Immunogen Information


Immunogen DescriptionSynthetic peptide of Human MC2RTarget SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ01718
Background Information
  • Uniprot Id

    Q01718

  • Target Species

    Human

  • Target Name

    MC2R

  • Target Full Name

    Adrenocorticotropic hormone receptor

  • Target Function

    Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

  • Target Involvement

    Glucocorticoid deficiency 1 (GCCD1)

  • Target Subcellular Location

    Cell membrane; Multi-pass membrane protein.

  • Target Protein Families

    G-protein coupled receptor 1 family

  • Target Tissue Specificity

    Melanocytes and corticoadrenal tissue.

  • Target Synonyms

    ACTHR; MC2R

  • Target Background

    MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene.

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