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The antibody against MCUB was raised in rabbit using the Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC, IF.
The antibody against MCUB was raised in rabbit using the Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using MCUB Antibody at dilution of 1:100
Immunofluorescent analysis of A549 cells using MCUB Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-25159A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MCUB |
| Target Synonyms | MCUB; CCDC109B; Calcium uniporter regulatory subunit MCUb, mitochondrial; MCUb; Coiled-coil domain-containing protein 109B | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NWR8 |
Uniprot Id
Q9NWR8
Target Species
Human
Target Name
MCUB
Target Full Name
Calcium uniporter regulatory subunit MCUb, mitochondrial
Target Function
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
MCU (TC 1.A.77) family
Target Synonyms
MCUB; CCDC109B; Calcium uniporter regulatory subunit MCUb, mitochondrial; MCUb; Coiled-coil domain-containing protein 109B
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