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The antibody against MEIKIN was raised in rabbit using the Recombinant Human Meiosis-specific kinetochore protein (18-91AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MEIKIN was raised in rabbit using the Recombinant Human Meiosis-specific kinetochore protein (18-91AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human placenta tissue using MEIKIN Antibody at dilution of 1:100
| Cat.No | ADC-14393A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MEIKIN |
| Target Synonyms | MEIKINMeiosis-specific kinetochore protein antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Meiosis-specific kinetochore protein (18-91AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A0A087WXM9 |
Uniprot Id
A0A087WXM9
Target Species
Human
Target Name
MEIKIN
Target Full Name
Meiosis-specific kinetochore protein
Target Function
Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.
Target Subcellular Location
Chromosome, centromere. Chromosome, centromere, kinetochore.
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