Rabbit anti-Human MEST Polyclonal Antibody

Uniprot Id

Q5EB52

Target Species

Human

Target Name

MEST

Target Full Name

Mesoderm-specific transcript homolog protein

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

AB hydrolase superfamily

Target Tissue Specificity

Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is exp

Target Synonyms

MEST; PEG1; Mesoderm-specific transcript homolog protein; Paternally-expressed gene 1 protein

Target Background

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15.