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The antibody against METTL14 was raised in rabbit using the Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against METTL14 was raised in rabbit using the Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western BlotPositive WB detected in: SH-SY5Y whole cell lysateAll lanes: METTL14 antibody at 1:1000SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 kDaObserved band size: 53 kDa
| Cat.No | ADC-14150A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | METTL14 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HCE5 |
Uniprot Id
Q9HCE5
Target Species
Human
Target Name
METTL14
Target Full Name
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14
Target Function
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.
Target Subcellular Location
Nucleus.
Target Protein Families
MT-A70-like family
Target Research Area
Cell Biology
Target Synonyms
KIAA1627; MET14_HUMAN; Methyltransferase like 14; Methyltransferase-like protein 14; METTL14; N6-adenosine-methyltransferase subunit METTL14; OTTHUMP00000219837
Target Background
Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex.
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