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The antibody against MPZL1 was raised in rabbit using the Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against MPZL1 was raised in rabbit using the Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human heart tissue using MPZL1 Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using MPZL1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-14653A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MPZL1 |
| Target Synonyms | MPZL1; PZR; UNQ849/PRO1787; Myelin protein zero-like protein 1; Protein zero-related | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95297 |
Uniprot Id
O95297
Target Species
Human
Target Name
MPZL1
Target Full Name
Myelin protein zero-like protein 1
Target Function
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Myelin P0 protein family
Target Tissue Specificity
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appe
Target Synonyms
MPZL1; PZR; UNQ849/PRO1787; Myelin protein zero-like protein 1; Protein zero-related
Target Background
Predicted to enable structural molecule activity. Predicted to be involved in cell-cell signaling and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within positive regulation of cell migration. Located in cell surface and focal adhesion.
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