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The antibody against MT2A was raised in rabbit using the Recombinant Human Metallothionein-2 protein (1-59AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MT2A was raised in rabbit using the Recombinant Human Metallothionein-2 protein (1-59AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using MT2A Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using MT2A Antibody at dilution of 1:1002
| Cat.No | ADC-46376A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MT2A |
| Target Synonyms | MT2A antibody; CES1 antibody; MT2 antibody; Metallothionein-2 antibody; MT-2 antibody; Metallothionein-2A antibody; Metallothionein-II antibody; MT-II antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Metallothionein-2 protein (1-59AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P02795 |
Uniprot Id
P02795
Target Species
Human
Target Name
MT2A
Target Full Name
Metallothionein-2
Target Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Target Protein Families
Metallothionein superfamily, Type 1 family
Target Synonyms
MT2A; CES1; MT2; Metallothionein-2; MT-2; Metallothionein-2A; Metallothionein-II; MT-II
Target Background
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer.
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