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The antibody against MYH2 was raised in rabbit using the Recombinant Human Myosin-2 protein (1154-1300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against MYH2 was raised in rabbit using the Recombinant Human Myosin-2 protein (1154-1300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate | All lanes: MYH2 antibody at 1:1250 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 224, 80 kDa | Observed band size: 224 kDa
| Cat.No | ADC-01940A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MYH2 |
| Target Synonyms | adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Myosin-2 protein (1154-1300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UKX2 |
Uniprot Id
Q9UKX2
Target Species
Human
Target Name
MYH2
Target Full Name
Myosin-2
Target Function
Muscle contraction. Required for cytoskeleton organization.
Target Involvement
Myopathy, proximal, and ophthalmoplegia (MYPOP)
Target Subcellular Location
Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Target Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Target Synonyms
adult 2; Fast 2a myosin heavy chain; IBM3; Inclusion body myopathy 3, autosomal dominant; MYH2; MYH2_HUMAN; MYH2A; MYHas8; MyHC IIa; MyHC-2a; MyHC-IIa; MYHSA2; Myosin heavy chain 2; Myosin heavy chain 2a; Myosin heavy chain; Myosin heavy chain IIa; Myosin heavy chain skeletal muscle adult 2; Myosin heavy polypeptide 2 skeletal muscle adult; Myosin-2; MYPOP; skeletal muscle; Type IIA myosin heavy chain
Target Background
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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