Rabbit anti-Human N-Myc/MYCN Polyclonal Antibody

The antibody against N-Myc/MYCN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN (NP_005369.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-12254A

Number

Cat.No	ADA-12254A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	N-Myc/MYCN
Target Synonyms	NMYC; ODED; MODED; N-myc; bHLHe37; MYCNsORF; MYCNsPEP; N-Myc/MYCN	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-12254A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

N-Myc/MYCN

Target Synonyms

NMYC; ODED; MODED; N-myc; bHLHe37; MYCNsORF; MYCNsPEP; N-Myc/MYCN

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN (NP_005369.2).	Target Species	Human
Immunogen Sequence	AGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDED	Uniprot ID	P04198

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN (NP_005369.2).

Target Species

Human

Immunogen Sequence

AGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDED

Uniprot ID

P04198

Background Information

Uniprot Id

P04198
Target Species

Human
Target Name

MYCN
Target Full Name

N-myc proto-oncogene protein
Target Function

Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Target Involvement

Feingold syndrome 1 (FGLDS1)
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
Target Research Area

Cancer
Target Synonyms

bHLHe37; Class E basic helix-loop-helix protein 37; MODED; mycn; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; Neuroblastoma MYC oncogene; NMYC; NMYC proto oncogene protein; ODED; Oncogene NMYC; pp65/67; V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v myc avian myelocytomatosis viral related oncogene neuroblastoma derived; v myc myelocytomatosis viral related oncogene neuroblastoma derived
Target Background

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human N-Myc/MYCN Polyclonal Antibody

Specifications

Immunogen Information

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