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The antibody against NAT2 was raised in rabbit using the Recombinant Human Arylamine N-acetyltransferase 2 protein (1-290AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against NAT2 was raised in rabbit using the Recombinant Human Arylamine N-acetyltransferase 2 protein (1-290AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using NAT2 Antibody at dilution of 1:1002
| Cat.No | ADC-24289A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NAT2 |
| Target Synonyms | AAC2 antibody; ARY2_HUMAN antibody; Arylamide acetylase 2 (N-acetyltransferase 2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Arylamine N-acetyltransferase 2 protein (1-290AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P11245 |
Uniprot Id
P11245
Target Species
Human
Target Name
NAT2
Target Full Name
Arylamine N-acetyltransferase 2
Target Function
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Arylamine N-acetyltransferase family
Target Research Area
Signal Transduction
Target Synonyms
AAC2; ARY2_HUMAN; Arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation); Arylamide acetylase 2; Arylamine N-acetyltransferase 2; HGNC:7646; N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; NAT-2; NAT2; PNAT; Polymorphic arylamine N-acetyltransferase
Target Background
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2).
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