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The antibody against NCOR2 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SMRTe. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
The antibody against NCOR2 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SMRTe. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
$167.00
| Cat.No | ADC-33261A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NCOR2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human SMRTe. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y618 |
Uniprot Id
Q9Y618
Target Species
Human
Target Name
NCOR2
Target Full Name
Nuclear receptor corepressor 2
Target Function
Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.
Target Subcellular Location
Nucleus.
Target Protein Families
N-CoR nuclear receptor corepressors family
Target Tissue Specificity
Ubiquitous. High levels of expression are detected in lung, spleen and brain.
Target Research Area
Cancer
Target Synonyms
CTG 26; CTG repeat protein 26; CTG26; N CoR2; N-CoR2; NCoR 2; Ncor2; NCOR2_HUMAN; Nuclear Receptor Co-Repressor 2; Nuclear receptor corepressor 2; retinoic-acid-receptor-associated corepressor; Silencing Mediator for Retanoid and Thyroid Hormone Receptors; Silencing mediator of retinoic acid and thyroid hormone receptor; SMAP 270; SMAP270; SMRT; SMRTE; SMRTE tau; T3 receptor associating factor; T3 receptor-associating factor; Thyroid retinoic acid receptor associated corepressor; Thyroid-; TNRC 14; TNRC14; TRAC 1; TRAC; TRAC1
Target Background
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.
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