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The antibody against NLGN1 was raised in rabbit using the Recombinant Human Neuroligin-1 protein (51-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against NLGN1 was raised in rabbit using the Recombinant Human Neuroligin-1 protein (51-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human brain tissue using NLGN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using NLGN1 Antibody at dilution of 1:1002
Immunofluorescent analysis of MCF-7 cells using NLGN1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-10227A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NLGN1 |
| Target Synonyms | NLG 1 antibody; KIAA1070 antibody; MGC45115 antibody; Neuroligin-1 antibody; NL1 antibody; NLG1 antibody; Nlgn1 antibody; NLGN1_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Neuroligin-1 protein (51-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N2Q7 |
Uniprot Id
Q8N2Q7
Target Species
Human
Target Name
NLGN1
Target Full Name
Neuroligin-1
Target Function
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cleft. Cell junction, synapse, synaptic cell membrane.
Target Protein Families
Type-B carboxylesterase/lipase family
Target Tissue Specificity
Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
Target Synonyms
NLG 1; KIAA1070; MGC45115; Neuroligin-1; NL1; NLG1; Nlgn1; NLGN1_HUMAN
Target Background
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
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