Rabbit anti-Human NOS1 Polyclonal Antibody

Uniprot Id

P29475

Target Species

Human

Target Name

NOS1

Target Full Name

Nitric oxide synthase 1

Target Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Target Subcellular Location

Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine.

Target Protein Families

NOS family

Target Tissue Specificity

Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected

Target Synonyms

2310005C01Rik; BNOS; Constitutive NOS; EC 1.14.13.39 ; IHPS 1; IHPS1 ; N-NOS; NC-NOS; neuronal Nitric Oxide Synthase; Neuronal NOS; Nitric oxide synthase ; neuronal; included; Nitric oxide synthase 1 (neuronal); Nitric oxide synthase 1; Nitric oxide synthase; brain; Nitric oxide synthase; penile neuronal; included; NNOS; NO; NOS 1; NOS; NOS type I; NOS-I; NOS1; NOS1_HUMAN; Peptidyl-cysteine S-nitrosylase NOS1

Target Background

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.