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The antibody against NOTUM was raised in rabbit using the Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM protein (100-235AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against NOTUM was raised in rabbit using the Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM protein (100-235AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-13756A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NOTUM |
| Target Synonyms | NOTUM antibody; notum pectinacetylesterase homolog (Drosophila) antibody; Notum pectinacetylesterase homolog antibody; NOTUM_HUMAN antibody; Protein notum homolog antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM protein (100-235AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6P988 |
Uniprot Id
Q6P988
Target Species
Human
Target Name
NOTUM
Target Full Name
Palmitoleoyl-protein carboxylesterase NOTUM
Target Function
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Target Subcellular Location
Secreted.
Target Protein Families
Pectinacetylesterase family, Notum subfamily
Target Tissue Specificity
Rarely expressed in adult normal tissues.
Target Research Area
Neuroscience
Target Synonyms
NOTUM; notum pectinacetylesterase homolog (Drosophila) ; Notum pectinacetylesterase homolog; NOTUM_HUMAN; Protein notum homolog
Target Background
Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region.
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