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The antibody against NUAK2 was raised in rabbit using the Recombinant Human NUAK family SNF1-like kinase 2 protein (479-628AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against NUAK2 was raised in rabbit using the Recombinant Human NUAK family SNF1-like kinase 2 protein (479-628AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using NUAK2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using NUAK2 Antibody at dilution of 1:1002
| Cat.No | ADC-16915A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NUAK2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human NUAK family SNF1-like kinase 2 protein (479-628AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H093 |
Uniprot Id
Q9H093
Target Species
Human
Target Name
NUAK2
Target Full Name
NUAK family SNF1-like kinase 2
Target Function
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
Target Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Target Synonyms
DKFZp434J037; DKFZp686F01113; FLJ90349; NUAK family SNF1 like kinase 2; NUAK family SNF1-like kinase 2; Nuak2; NUAK2_HUMAN; Omphalocele kinase 2; SNARK; SNF1/AMP activated protein kinase ; SNF1/AMP kinase related kinase; SNF1/AMP kinase-related kinase
Target Background
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; negative regulation of apoptotic process; and protein phosphorylation. Predicted to be active in cytoplasm. Implicated in anencephaly.
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