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The antibody against PAM16 was raised in rabbit using the Recombinant Human Mitochondrial import inner membrane translocase subunit TIM16 protein (1-125AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PAM16 was raised in rabbit using the Recombinant Human Mitochondrial import inner membrane translocase subunit TIM16 protein (1-125AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-50537A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAM16 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mitochondrial import inner membrane translocase subunit TIM16 protein (1-125AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y3D7 |
Uniprot Id
Q9Y3D7
Target Species
Human
Target Name
PAM16
Target Full Name
Mitochondrial import inner membrane translocase subunit TIM16
Target Function
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.
Target Involvement
Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type (SMDMDM)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families
TIM16/PAM16 family
Target Tissue Specificity
Ubiquitously expressed.
Target Research Area
Signal Transduction
Target Synonyms
CGI-136; MAGMAS; Magmas like protein; Mitochondria associated protein involved in granulocyte macrophage colony stimulating factor signal transduction; Mitochondria-associated granulocyte macrophage CSF-signaling molecule; Mitochondrial import inner membrane translocase subunit TIM16; PAM16; Presequence translocase-associated motor 16 homolog (S. cerevisiae); Presequence translocated-associated motor subunit PAM16; TIM16; TIM16_HUMAN; TIMM16
Target Background
This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities.
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