Rabbit anti-Human PBXIP1 Polyclonal Antibody

Uniprot Id

Q96AQ6

Target Species

Human

Target Name

PBXIP1

Target Full Name

Pre-B-cell leukemia transcription factor-interacting protein 1

Target Function

Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

Target Subcellular Location

Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).

Target Tissue Specificity

Expressed in early hematopoietic precursors.

Target Synonyms

PBXIP1; HPIPPre-B-cell leukemia transcription factor-interacting protein 1; Hematopoietic PBX-interacting protein

Target Background

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined.