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The antibody against PGAM5 was raised in rabbit using the Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial protein (30-223AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PGAM5 was raised in rabbit using the Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial protein (30-223AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using PGAM5 Antibody at dilution of 1: 100
Immunofluorescent analysis of Hela cells using PGAM5 Antibody at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-11426A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PGAM5 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial protein (30-223AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96HS1 |
Uniprot Id
Q96HS1
Target Species
Human
Target Name
PGAM5
Target Full Name
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Target Function
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
Target Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Target Protein Families
Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
Target Research Area
Cancer
Target Synonyms
Bcl-XL-binding protein v68; BXLBv68; MGC5352; mitochondrial; PGAM5; PGAM5_HUMAN; Phosphoglycerate mutase family member 5; Serine/threonine protein phosphatase PGAM5 mitochondrial; Serine/threonine-protein phosphatase PGAM5
Target Background
Enables GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process. Located in mitochondrion.
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