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The antibody against PHC1 was raised in rabbit using the Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PHC1 was raised in rabbit using the Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using PHC1 Antibody at dilution of 1:100
| Cat.No | ADC-15794A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHC1 |
| Target Synonyms | Early development regulatory protein 1 antibody; hPH1 antibody; mPH1 antibody; PH1 antibody; Phc1 antibody; PHC1_HUMAN antibody; Polyhomeotic-like protein 1 antibody; Rae28 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P78364 |
Uniprot Id
P78364
Target Species
Human
Target Name
PHC1
Target Full Name
Polyhomeotic-like protein 1
Target Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Target Involvement
Microcephaly 11, primary, autosomal recessive (MCPH11)
Target Subcellular Location
Nucleus.
Target Synonyms
Early development regulatory protein 1; hPH1; mPH1; PH1; Phc1; PHC1_HUMAN; Polyhomeotic-like protein 1; Rae28
Target Background
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
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