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The antibody against PHF21A was raised in rabbit using the Recombinant Human PHD finger protein 21A protein (312-487AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against PHF21A was raised in rabbit using the Recombinant Human PHD finger protein 21A protein (312-487AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human liver cancer using PHF21A Antibody at dilution of 1:1002
| Cat.No | ADC-10915A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHF21A |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human PHD finger protein 21A protein (312-487AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96BD5 |
Uniprot Id
Q96BD5
Target Species
Human
Target Name
PHF21A
Target Full Name
PHD finger protein 21A
Target Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Highly expressed in brain. Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle. Abundantly expressed in fetal brain.
Target Synonyms
BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A_HUMAN; PHD finger protein 21A; PHF21A
Target Background
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).
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