Rabbit anti-Human Phospho-WRN (S1141) Polyclonal Antibody

Uniprot Id

Q14191

Target Species

Human

Target Name

WRN

Target Full Name

Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Target Function

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Plays a role in double-strand break repair after gamma-irradiation.

Target Involvement

Werner syndrome (WRN); Colorectal cancer (CRC)

Target Subcellular Location

Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Chromosome.

Target Protein Families

Helicase family, RecQ subfamily

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

DKFZp686C2056; DNA helicase; DNA helicase, RecQ like type 3; Exonuclease WRN; HGNC 12791; OTTHUMP00000225301; RecQ protein-like 2; RecQ-like type 3; RecQ3; RECQL2; RECQL3; Werner syndrome ATP-dependent helicase; Werner syndrome helicase; Werner syndrome protein; Werner syndrome, RecQ helicase like; WRN; WRN_HUMAN

Target Background

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers.