Rabbit anti-Human PI4KB Polyclonal Antibody

Uniprot Id

Q9UBF8

Target Species

Human

Target Name

PI4KB

Target Full Name

Phosphatidylinositol 4-kinase beta

Target Function

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking.; (Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites.; (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.

Target Subcellular Location

Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Cytoplasm, perinuclear region.

Target Protein Families

PI3/PI4-kinase family, Type III PI4K subfamily

Target Tissue Specificity

Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.

Target Synonyms

DKFZp686O1820; FLJ30129; NPIK; Phosphatidylinositol 4 kinase beta; Phosphatidylinositol 4 kinase catalytic beta; Phosphatidylinositol 4 kinase catalytic beta polypeptide; Phosphatidylinositol 4 kinase wortmannin sensitive; Phosphatidylinositol 4-kinase beta; PI4K BETA; PI4K-beta; PI4K92; PI4KB; PI4KB_HUMAN; PI4Kbeta; PI4KIIIbeta; PIK4CB; PtdIns 4 kinase; PtdIns 4-kinase beta; Type III phosphatidylinositol 4 kinase beta

Target Background

Enables 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Located in Golgi membrane.