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The antibody against PLXNB2 was raised in rabbit using the Recombinant Human Inhibitor of nuclear factor kappa-B kinase-interacting protein (1458-1673AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PLXNB2 was raised in rabbit using the Recombinant Human Inhibitor of nuclear factor kappa-B kinase-interacting protein (1458-1673AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in: A549 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate | All lanes: PLXNB2 antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 206 kDa | Observed band size: 206 kDa
| Cat.No | ADC-00619A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLXNB2 |
| Target Synonyms | PLXNB2 antibody; KIAA0315 antibody; Plexin-B2 antibody; MM1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Antigen Affinity purified & Affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Inhibitor of nuclear factor kappa-B kinase-interacting protein (1458-1673AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15031 |
Uniprot Id
O15031
Target Species
Human
Target Name
PLXNB2
Target Full Name
Plexin-B2
Target Function
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Plexin family
Target Research Area
Neuroscience
Target Synonyms
PLXNB2; KIAA0315; Plexin-B2; MM1
Target Background
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).
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