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The antibody against PMVK was raised in rabbit using the Human PMVK as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against PMVK was raised in rabbit using the Human PMVK as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-47590A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMVK |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human PMVK | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15126 |
Uniprot Id
Q15126
Target Species
Human
Target Name
PMVK
Target Full Name
Phosphomevalonate kinase
Target Function
Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
Target Involvement
Porokeratosis 1, multiple types (POROK1)
Target Subcellular Location
Cytoplasm, cytosol.
Target Tissue Specificity
Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.
Target Synonyms
hPMK; HUMPMKI; OTTHUMP00000035546; Phosphomevalonate kinase; PMK; PMK PEN; PMKA; PMKase; PMKI; PMKPEN; PMVK; PMVK_HUMAN
Target Background
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants.
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