Rabbit anti-Human POF1B Polyclonal Antibody

Uniprot Id

Q8WVV4

Target Species

Human

Target Name

POF1B

Target Full Name

Protein POF1B

Target Function

Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.

Target Involvement

Premature ovarian failure 2B (POF2B)

Target Subcellular Location

Cell junction, tight junction.

Target Synonyms

2310066B14Rik; FLJ22792; POF; Pof1b; POF1B_HUMAN; POF2B; Premature ovarian failure protein 1B; Protein POF1B; RGD1560798; RP1-75N13.2; RP23-336F13.1

Target Background

Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.