Rabbit anti-Human POLR2D Polyclonal Antibody

Uniprot Id

O15514

Target Species

Human

Target Name

POLR2D

Target Full Name

DNA-directed RNA polymerase II subunit RPB4

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA.

Target Subcellular Location

Nucleus.

Target Protein Families

Eukaryotic RPB4 RNA polymerase subunit family

Target Synonyms

DNA directed RNA polymerase II 16 kDa polypeptide; DNA directed RNA polymerase II subunit D; DNA directed RNA polymerase II subunit RPB4; DNA-directed RNA polymerase II 16 kDa polypeptide ; DNA-directed RNA polymerase II subunit D; DNA-directed RNA polymerase II subunit rpb4; HSRBP4; HSRPB4; polr2d; polymerase RNA II DNA directed polypeptide D; RBP4; RNA polymerase II 16 kDa subunit; RNA polymerase II subunit B4; RNA polymerase II subunit D; RNA polymerase II subunit hsRBP4; RPB16; RPB4_HUMAN

Target Background

This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene.