Rabbit anti-Human POSTN Polyclonal Antibody

Uniprot Id

Q15063

Target Species

Human

Target Name

POSTN

Target Full Name

Periostin

Target Function

Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX.

Target Subcellular Location

Golgi apparatus. Secreted. Secreted, extracellular space, extracellular matrix.

Target Tissue Specificity

Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of

Target Synonyms

PN; OSF2; OSF-2; PDLPOSTN; POSTN

Target Background

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms.