Rabbit anti-Human PPARGC1A Polyclonal Antibody

Uniprot Id

Q9UBK2

Target Species

Human

Target Name

PPARGC1A

Target Full Name

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Target Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Target Subcellular Location

[Isoform 1]: Nucleus. Nucleus, PML body.; [Isoform B4]: Nucleus.; [Isoform B4-8a]: Cytoplasm. Nucleus.; [Isoform B5]: Nucleus. Nucleus, PML body.; [Isoform 9]: Nucleus.

Target Tissue Specificity

Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold i

Target Research Area

Cardiovascular

Target Synonyms

L PGC 1alpha; LEM6; Ligand effect modulator 6; Peroxisome proliferative activated receptor gamma coactivator 1 alpha; Peroxisome proliferative activated receptor gamma coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 3ext; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 8a; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5 NT; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1-alpha; PGC1; PGC1(alpha); PGC1A; PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A; PRGC1_HUMAN

Target Background

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.