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The antibody against PPT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-306 of human PPT1 (NP_000301.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PPT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-306 of human PPT1 (NP_000301.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10168A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPT1 |
| Target Synonyms | PPT; CLN1; INCL; PPT1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat brain, LO2, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 28-306 of human PPT1 (NP_000301.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P50897 | Immunogen Sequence |
Uniprot Id
P50897
Target Species
Human
Target Name
PPT1
Target Full Name
Palmitoyl-protein thioesterase 1
Target Function
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
Target Involvement
Ceroid lipofuscinosis, neuronal, 1 (CLN1)
Target Subcellular Location
Lysosome. Secreted.
Target Protein Families
Palmitoyl-protein thioesterase family
Target Synonyms
Ceroid palmitoyl palmitoyl protein thioesterase 1; CLN1; EC 3.1.2.22; INCL; Palmitoyl protein hydrolase 1 ; Palmitoyl protein thioesterase 1; Palmitoyl-protein hydrolase 1; Palmitoyl-protein thioesterase 1; PPT; PPT-1; PPT1; PPT1_HUMAN
Target Background
The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.
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