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The antibody against PRRX1 was raised in rabbit using the Synthesized peptide derived from Internal of Human PRRX1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against PRRX1 was raised in rabbit using the Synthesized peptide derived from Internal of Human PRRX1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from NIH-3T3/K562 cells, using PRRX1 antibody.
| Cat.No | ADC-41056A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRRX1 |
| Target Synonyms | 2 antibody; PHOX1 antibody; PMX 1 antibody; PMX1 antibody; PRRX 1 antibody; Prrx1 antibody; PRRX1_HUMAN antibody; PRX 1 antibody; PRX-1 antibody; PRX1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Internal of Human PRRX1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P54821 |
Uniprot Id
P54821
Target Species
Human
Target Name
PRRX1
Target Full Name
Paired mesoderm homeobox protein 1
Target Function
Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
Target Involvement
Agnathia-otocephaly complex (AGOTC)
Target Subcellular Location
Nucleus.
Target Protein Families
Paired homeobox family
Target Synonyms
AGOTC; Homeobox protein PHOX1; Paired mesoderm homeo box 1; Paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired related homeobox 1; Paired related homeobox protein 1; Paired-related homeobox protein 1; PHOX 1; PHOX1 1, 2; PHOX1; PMX 1; PMX1; PRRX 1; Prrx1; PRRX1_HUMAN; PRX 1 ; PRX-1; PRX1
Target Background
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.
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