Rabbit anti-Human PTPN22 Polyclonal Antibody

Uniprot Id

Q9Y2R2

Target Species

Human

Target Name

PTPN22

Target Full Name

Tyrosine-protein phosphatase non-receptor type 22

Target Function

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide).

Target Involvement

Systemic lupus erythematosus (SLE); Diabetes mellitus, insulin-dependent (IDDM); Rheumatoid arthritis (RA); Vitiligo (VTLG)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily

Target Tissue Specificity

Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils. Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-

Target Synonyms

LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6; PTPN22

Target Background

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.