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The antibody against PYHIN1 was raised in rabbit using the Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PYHIN1 was raised in rabbit using the Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-19739A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PYHIN1 |
| Target Synonyms | IFIX_HUMAN antibody; Interferon-inducible protein X antibody; Pyhin1 antibody; Pyrin and HIN domain-containing protein 1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6K0P9 |
Uniprot Id
Q6K0P9
Target Species
Human
Target Name
PYHIN1
Target Full Name
Pyrin and HIN domain-containing protein 1
Target Function
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Target Subcellular Location
[Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.
Target Protein Families
HIN-200 family
Target Tissue Specificity
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Target Synonyms
IFIX_HUMAN; Interferon-inducible protein X; Pyhin1; Pyrin and HIN domain-containing protein 1
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