Rabbit anti-Human RAB12 Polyclonal Antibody

The antibody against RAB12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human RAB12 (NP_001020471.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00660A

Number

Cat.No	ADA-00660A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	RAB12
Target Synonyms	RAB12	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	NIH/3T3, Mouse lung	Application	ELISA, WB

Cat.No

ADA-00660A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

RAB12

Target Synonyms

RAB12

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

NIH/3T3, Mouse lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human RAB12 (NP_001020471.2).	Target Species	Human
Immunogen Sequence	MDPGAALQRRAGGGGGLGAGSPALSGGQGRRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEA	Uniprot ID	Q6IQ22

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human RAB12 (NP_001020471.2).

Target Species

Human

Immunogen Sequence

MDPGAALQRRAGGGGGLGAGSPALSGGQGRRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEA

Uniprot ID

Q6IQ22

Background Information

Uniprot Id

Q6IQ22
Target Species

Human
Target Name

RAB12
Target Full Name

Ras-related protein Rab-12
Target Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
Target Subcellular Location

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome.
Target Protein Families

Small GTPase superfamily, Rab family
Target Research Area

Neuroscience
Target Synonyms

Putative Ras related protein Rab 12; RAB12; RAB12; member RAS oncogene family; RAB12_HUMAN; Ras-related protein Rab-12
Target Background

Enables GDP binding activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; endosome to lysosome transport; and secretion by cell. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane.

Rabbit anti-Human RAB12 Polyclonal Antibody

Specifications

Immunogen Information

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