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The antibody against RFK was raised in rabbit using the Recombinant Human Riboflavin kinase protein (1-154AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against RFK was raised in rabbit using the Recombinant Human Riboflavin kinase protein (1-154AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human prostate cancer using RFK Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using RFK Antibody at dilution of 1:1002
Immunofluorescent analysis of A549 cells using RFK Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-19023A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RFK |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Riboflavin kinase protein (1-154AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q969G6 |
Uniprot Id
Q969G6
Target Species
Human
Target Name
RFK
Target Full Name
Riboflavin kinase
Target Function
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Detected in brain, placenta and urinary bladder.
Target Synonyms
0610038L10Rik; AF031381; ATP:riboflavin 5' phosphotransferase; ATP:riboflavin 5''-phosphotransferase; Flavokinase; FLJ11149; KOI 4; Rfk; Riboflavin kinase; RIFK; RIFK_HUMAN; RP11-422N19.2
Target Background
Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).
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