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The antibody against RGS2 was raised in rabbit using the Recombinant Human Regulator of G-protein signaling 2 protein (1-211AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against RGS2 was raised in rabbit using the Recombinant Human Regulator of G-protein signaling 2 protein (1-211AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human heart tissue using RGS2 Antibody at dilution of 1:1002
| Cat.No | ADC-45005A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RGS2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Regulator of G-protein signaling 2 protein (1-211AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P41220 |
Uniprot Id
P41220
Target Species
Human
Target Name
RGS2
Target Full Name
Regulator of G-protein signaling 2
Target Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Target Subcellular Location
[Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 3]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 4]: Cell membrane. Mitochondrion.
Target Tissue Specificity
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Target Synonyms
Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; G0S8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulator of G-protein signaling 2; Regulators of G protein signaling XRGSVI; RGS 2; RGS2; RGS2_HUMAN
Target Background
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.
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