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The antibody against RIDA was raised in rabbit using the Recombinant Human 2-iminobutanoate/2-iminopropanoate deaminase protein (2-137AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against RIDA was raised in rabbit using the Recombinant Human 2-iminobutanoate/2-iminopropanoate deaminase protein (2-137AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human liver tissue using RIDA Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using RIDA Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-21993A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RIDA |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human 2-iminobutanoate/2-iminopropanoate deaminase protein (2-137AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P52758 |
Uniprot Id
P52758
Target Species
Human
Target Name
RIDA
Target Full Name
2-iminobutanoate/2-iminopropanoate deaminase
Target Function
Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
Target Subcellular Location
Cytoplasm. Nucleus. Peroxisome. Mitochondrion.
Target Protein Families
RutC family
Target Tissue Specificity
Expressed predominantly in liver and kidney. Lower levels in lung and brain.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; Heat responsive protein 12; Heat-responsive protein 12; Hrsp12; p14.5; Perchloric acid soluble protein; PSP; Reactive intermediate imine deaminase A homolog; Ribonuclease UK114; RIDA; Translational inhibitor p14.5; Translational inhibitor protein p14.5; UK114; UK114 antigen homolog; UK114_HUMAN
Target Background
Enables 2-iminobutanoate deaminase activity and mRNA binding activity. Involved in mRNA catabolic process; mRNA destabilization; and organonitrogen compound catabolic process. Located in cytoplasm and nucleus.
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